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Fat Metabolism

Step by step fat metabolism


1.   Bile salts emulsify dietary fats in the small intestine, forming mixed micelles.

2.   Intestinal lipases degrade tricylglycerols.

3.   Fatty acids and other breakdown products are taken up by the intestinal mucosa and converted into triacylglycerols.

4.   Triacylglycerols are incorporated with cholesterol and apoproteins into chylomicrons.

5.   Chylomicrons move through the lymphatic system and bloodstream to tissues.

6.   Lipoproteins lipase, activated by apoC-II in the capillary, releases fatty acids and glycerol.

7.   Fatty acids enter cells.

8.   Fatty acids are oxidized as fuel or re-esterified for storage.


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